Our current and previous work in hypertension and renal disease has laid the groundwork for expanding these findings to other renal disease models such as polycystic kidney disease (PKD). Using a combination of telemetry-based measurements and molecular interrogation, we are currently leveraging this unique experimental approach to elucidate the physiological relationship between changes in renal afferent nerve activity and hypertension-induced renal inflammation and the concomitant autonomic dysfunction. My focus has now expanded to addressing the crucial questions of when and how changes in renal nerve activity modulate arterial pressure control. sensory) and sympathetic contributions to DOCA-salt model of hypertension through selective denervations, demonstrating the central role for afferent renal nerves in the disease etiology. My recent work has differentiated between afferent (i.e. Thus, our studies aim to elucidate the detailed mechanisms of renal nerves in hypertension and other renal diseases (polycystic kidney disease ischemia-reperfusion injury etc.) to provide a translational platform for development and refinement of emerging antihypertensive therapies. While the anti-hypertensive effects are exciting, the mechanisms mediating the beneficial effects are unclear. This was motivated, in part, by recent advancements in catheter-based targeted nerve ablation of renal nerves in humans, which mitigates or even reverses drug-resistant hypertension. While hypertension is a multi-faceted disease, I have focused my research primarily on neural (brain) and renal (kidney) contributions to the development and maintenance of hypertension. Professor Fink has been a member of the Association of Orthodox Jewish Scientists.Throughout my career, I have focused on the physiological underpinnings of the etiology and treatment of high blood pressure (i.e. A long-time, avid interest in the philosophy of science and epistemology, as well as an increasing interest in the history, values and metaphysics of traditional Judaism has made the subject of evolution/creation a favorite scholarly avocation. Professor Fink resides in the Pico-Robertson area of Los Angeles with his wife of 30 years and their four daughters and son. He was commissioned by the California State Community College System to develop the curriculum for an Environmental Toxicology-Industrial Hygiene course for all community colleges in California. Professor Fink has published in the American Journal of Physiology and the The Physiologist, has written texts in Human Physiology, Pharmacology for Dental Hygienists, and a widely-used Biology Laboratory Manual. More recently he completed further studies in the area of Environmental and Occupational Health.
Prior to his appointment, he completed his Baccalaureate Degree at the University of California at Davis, and completed his Masters Degree and Doctoral studies at the University of California Medical Center at San Francisco. For the past 30 years his primary instructional responsibilities have been in the areas of Human Physiology, Clinical Pharmacology and Environmental Toxicology.
He is also Adjunct Professor of Pharmacology for the West Los Angeles College Dental Hygiene Program, and Adjunct Associate Professor for Anatomy & Physiology in the Life-Sciences Department at Santa Monica College. Fink is Professor of Biological Sciences, Vice-Chairman of the Sciences Division, and Director of the Environmental Hazardous Materials Technology Program at West Los Angeles College.
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